氨甲环酸减少择期剖宫产术后出血的疗效评价与血红蛋白下降的参考

J. Gulzar, S. Zahra, I. Aftab, Nayab Amir, Rana Muhammad Naeem Liaqat, Ayesha Iqbal
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摘要

产科出血是阴道分娩或剖宫产的潜在致命临床表现。据报道,几乎50%的与怀孕有关的死亡都是由它造成的。无论是在低收入国家还是在发达国家,剖腹产的流行率都急剧上升,从而增加了产科出血的可能性。本研究的基本原理是评估TA对LSCS失血量的疗效和安全性非常重要。方法:将病例分为病例组(A)和对照组(B)两组。在手术室,参与者分别获得A、B两种包装供其选择,其内容仅由负责药物配制的护士知晓。所有药物均由麻醉师注射,麻醉师不负责监督或评估患者。结果:两组治疗后Hb水平下降(>10%)的比较显示,A组6(20%)和B组15(50%)治疗后Hb水平下降>10%,p值=0.015。结论:TA治疗可显著减少CS全期出血,减少失血量大于1000ml的患者比例,减少补充子宫强直物质的需要量。因此,TA可以非常安全和成功地用于接受剖腹产的患者。
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Determining Efficacy of Tranexamic Acid in Reducing Post Partum Haemorrhage in Elective Cesarean Section Patients Evaluating in Referance to Fall in Haemoglobin
Obstetrical haemorrhage is a potentially fatal clinical manifestation of either vaginal delivery or caesarean section. According to reports, it is responsible for almost fifty percent of all pregnancy - related deaths. The prevalence of caesarean section (CS) has dramatically upped in both low income as well as in developed nations, thereby increasing the likelihood of obstetrical haemorrhage. The rationale of this study is that it is important to evaluate the efficacy and safety of TA on blood loss with LSCS. Methods: Cases were separated into two subgroups: case: (A) and control: (B). In the operating theater, participants were given A and B packages to choose from, the contents of whom were only known to the nurse in charge of drug preparation. All meds were injected by an anesthetist who was not in charge of supervising or assessing the patients. Results: Comparison of both %age reduction in Hb levels (>10%) after treatment shows that in Group A 6(20%) and in Group B 15(50%) had >10% reduction in Hb levels after treatment, p-value=0.015. Conclusion: TA administration reduced dramatically the bleeding throughout CS, the proportion of patients who lost more than 1000 mL of blood, and the requirement for supplemental uterotonic substances. As a result, TA can be employed very safely and successfully in patients receiving caesarean section.
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