7T BOLD成像中相关信号的空间尺度

A. Parker, H. Bridge, G. Coullon
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引用次数: 1

摘要

使用血氧水平依赖(BOLD)激活测量的磁共振成像(MRI)信号的空间分布对MRI解析来自大脑的神经信号的能力提出了基本限制。本研究表明,多个低水平BOLD活动样本构成了一种具有明显空间特征的神经“成像尘埃”。我们将距离相关的方差测量应用于BOLD信号的空间图,以提供一种估计MRI经验点扩散函数(PSF)的新方法。我们表明,这些新的估计与高场7-T成像的PSF的早期测量相似,但其优势在于它们是针对单个扫描会话中测试的每个个体的。我们探索了这种方法的各种潜在应用。
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Spatial scale of correlated signals in 7T BOLD imaging
The spatial distribution of signals from magnetic resonance imaging (MRI) using measures of Blood Oxygen Level Dependent (BOLD) activations presents a fundamental limit on the ability of MRI to resolve the neural signals from the brain. Here we show that the multiple samples of low-level BOLD activity comprise a form of neural “imaging dust” with distinct spatial characteristics. We apply the distance-dependent measurement of variance to spatial maps of BOLD signals to deliver a new approach to estimating the empirical point-spread function (PSF) of MRI. We show that these new estimates are similar to earlier measures of the PSF of high field 7-T imaging, but deliver the advantage that they are specific to each individual tested in a single scanning session. We explore various potential applications of this approach.
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