吡啶[1,2-a]嘧啶合成的新方法

Scholarly Research Exchange Pub Date : 2008-09-16 DOI:10.3814/2008/434329

R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak

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引用次数: 6

摘要

以二氢呋喃酮为中间体，成功地合成了以氯乙基为顽固性侧链的吡啶[1,2- A]嘧啶。以2-氨基吡啶与α -乙酰基- γ -丁内酯缩合为原料合成了二氢呋喃酮中间体，经氯化磷或乙醇在乙氧基钠中环化后得到了吡啶[1,2-a]，产率高。

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New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines

A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.

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