新辅助免疫疗法治疗少转移局部晚期结肠癌。临床病例

MD-Onco Pub Date : 2022-10-13 DOI:10.17650/2782-3202-2022-2-3-21-27

A. Rasulov, J. Madyarov, A. E. Kulikov, Z. Rasulov, L. A. Shestakova, D. Chekini, E. K. Ibragimov, E. Puchkova, Yu. E. Lvova, R. A. Rasulov

{"title":"新辅助免疫疗法治疗少转移局部晚期结肠癌。临床病例","authors":"A. Rasulov, J. Madyarov, A. E. Kulikov, Z. Rasulov, L. A. Shestakova, D. Chekini, E. K. Ibragimov, E. Puchkova, Yu. E. Lvova, R. A. Rasulov","doi":"10.17650/2782-3202-2022-2-3-21-27","DOIUrl":null,"url":null,"abstract":"Immunotherapy has improved the results of treatment of patients with metastatic colorectal cancer. According to literature, the most cancericidal effect revealed in a microsatellite instability high (MSI-H) tumors. In our case, PD-1/PD-L1/PD-L2 inhibitors (nivolumab) treatment for locally advanced MSI-H colon carcinoma with liver metastasis in 44-year-old patient resulted in tumor regression, so that R0 surgical procedure became possible. Computed tomography scan and pathology report showed complete response, in primary and metastatic tumors. As a result, this allowed to improve the quality of patient’s life.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neoadjuvant immunotherapy in treatment of oligometastatic locally advanced colon cancer. Clinical case\",\"authors\":\"A. Rasulov, J. Madyarov, A. E. Kulikov, Z. Rasulov, L. A. Shestakova, D. Chekini, E. K. Ibragimov, E. Puchkova, Yu. E. Lvova, R. A. Rasulov\",\"doi\":\"10.17650/2782-3202-2022-2-3-21-27\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Immunotherapy has improved the results of treatment of patients with metastatic colorectal cancer. According to literature, the most cancericidal effect revealed in a microsatellite instability high (MSI-H) tumors. In our case, PD-1/PD-L1/PD-L2 inhibitors (nivolumab) treatment for locally advanced MSI-H colon carcinoma with liver metastasis in 44-year-old patient resulted in tumor regression, so that R0 surgical procedure became possible. Computed tomography scan and pathology report showed complete response, in primary and metastatic tumors. As a result, this allowed to improve the quality of patient’s life.\",\"PeriodicalId\":318498,\"journal\":{\"name\":\"MD-Onco\",\"volume\":\"5 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"MD-Onco\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17650/2782-3202-2022-2-3-21-27\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"MD-Onco","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17650/2782-3202-2022-2-3-21-27","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

免疫疗法改善了转移性结直肠癌患者的治疗效果。据文献报道，在微卫星不稳定性高(MSI-H)肿瘤中显示出最大的杀癌作用。在我们的病例中，PD-1/PD-L1/PD-L2抑制剂(nivolumab)治疗44岁局部晚期MSI-H结肠癌伴肝转移患者导致肿瘤消退，因此R0手术成为可能。计算机断层扫描和病理报告显示完全缓解，在原发性和转移性肿瘤。因此，这可以改善病人的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Neoadjuvant immunotherapy in treatment of oligometastatic locally advanced colon cancer. Clinical case

Immunotherapy has improved the results of treatment of patients with metastatic colorectal cancer. According to literature, the most cancericidal effect revealed in a microsatellite instability high (MSI-H) tumors. In our case, PD-1/PD-L1/PD-L2 inhibitors (nivolumab) treatment for locally advanced MSI-H colon carcinoma with liver metastasis in 44-year-old patient resulted in tumor regression, so that R0 surgical procedure became possible. Computed tomography scan and pathology report showed complete response, in primary and metastatic tumors. As a result, this allowed to improve the quality of patient’s life.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

MD-Onco

自引率

0.00%

发文量