加纳疑似病毒性出血热患者病毒病原体的分子检测

J. H. Bonney, T. Asigbee, E. Kotey, Keren Attiku, F. Asiedu-Bekoe, Gifty Mawuli, E. Bonney, I. Asante, C. Z. Abana, D. Pratt, Stephen Nyarko, B. Sarkodie, W. Ampofo
{"title":"加纳疑似病毒性出血热患者病毒病原体的分子检测","authors":"J. H. Bonney, T. Asigbee, E. Kotey, Keren Attiku, F. Asiedu-Bekoe, Gifty Mawuli, E. Bonney, I. Asante, C. Z. Abana, D. Pratt, Stephen Nyarko, B. Sarkodie, W. Ampofo","doi":"10.46829/hsijournal.2020.6.1.1.31-35","DOIUrl":null,"url":null,"abstract":"Background: Viral hemorrhagic fevers (VHFs) are infectious illnesses that can cause serious morbidity and mortality to infected persons. During the 2014 Ebola virus disease outbreak in some West African countries, Ghana revamped its surveillance system across the country to prepare, effectively respond and pre-empt any public health concerns\n\nObjective: We report on suspected VHF clinical specimens submitted to the Noguchi Memorial Institute for Medical Research (NMIMR) from health facilities across the country for diagnosis within the period under review. This was partly to provide rapid response and to alert the health system to prevent outbreaks and its spread.\n\nMethods: From January 2017 to December 2018 clinical specimens of blood from 149 cases of suspected VHFs were collected at health facilities across the country and sent to NMIMR. Patient specimens were tested for viral pathogens including Lassa fever, Yellow fever, Dengue fever, Chikungunya, Zika, Ebola and Marburg by real-time reverse transcription-polymerase chain reaction. A case was however tested for influenza as the patient exhibited respiratory distress symptoms as well. Demographic and clinical information collected on a structured case-based forms were analyzed for each patient.\n\nResults: Out of the 149 clinical specimens tested, three (3) were found to be positive, with two (2) being Dengue and one (1) seasonal Influenza A H1N1. Analysis of the case-based forms revealed shortcomings with regards to standard case definitions used to enroll suspected cases.\n\nConclusion: Our results buttress the need for a routine surveillance activity for VHFs to minimize spread and possibly forestall outbreaks. Moreover, febrile illnesses can be caused by a host of pathogens hence there is a need for enhanced diagnosis to help in patient management.","PeriodicalId":285465,"journal":{"name":"Health Sciences Investigations Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Molecular detection of viral pathogens from suspected viral hemorrhagic fever patients in Ghana\",\"authors\":\"J. H. Bonney, T. Asigbee, E. Kotey, Keren Attiku, F. Asiedu-Bekoe, Gifty Mawuli, E. Bonney, I. Asante, C. Z. Abana, D. Pratt, Stephen Nyarko, B. Sarkodie, W. Ampofo\",\"doi\":\"10.46829/hsijournal.2020.6.1.1.31-35\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Viral hemorrhagic fevers (VHFs) are infectious illnesses that can cause serious morbidity and mortality to infected persons. During the 2014 Ebola virus disease outbreak in some West African countries, Ghana revamped its surveillance system across the country to prepare, effectively respond and pre-empt any public health concerns\\n\\nObjective: We report on suspected VHF clinical specimens submitted to the Noguchi Memorial Institute for Medical Research (NMIMR) from health facilities across the country for diagnosis within the period under review. This was partly to provide rapid response and to alert the health system to prevent outbreaks and its spread.\\n\\nMethods: From January 2017 to December 2018 clinical specimens of blood from 149 cases of suspected VHFs were collected at health facilities across the country and sent to NMIMR. Patient specimens were tested for viral pathogens including Lassa fever, Yellow fever, Dengue fever, Chikungunya, Zika, Ebola and Marburg by real-time reverse transcription-polymerase chain reaction. A case was however tested for influenza as the patient exhibited respiratory distress symptoms as well. Demographic and clinical information collected on a structured case-based forms were analyzed for each patient.\\n\\nResults: Out of the 149 clinical specimens tested, three (3) were found to be positive, with two (2) being Dengue and one (1) seasonal Influenza A H1N1. Analysis of the case-based forms revealed shortcomings with regards to standard case definitions used to enroll suspected cases.\\n\\nConclusion: Our results buttress the need for a routine surveillance activity for VHFs to minimize spread and possibly forestall outbreaks. Moreover, febrile illnesses can be caused by a host of pathogens hence there is a need for enhanced diagnosis to help in patient management.\",\"PeriodicalId\":285465,\"journal\":{\"name\":\"Health Sciences Investigations Journal\",\"volume\":\"7 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Sciences Investigations Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46829/hsijournal.2020.6.1.1.31-35\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Sciences Investigations Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46829/hsijournal.2020.6.1.1.31-35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

背景:病毒性出血热(VHFs)是一种传染性疾病,可引起严重的发病率和死亡率。在2014年西非一些国家爆发埃博拉病毒病期间,加纳在全国范围内改进了监测系统,以准备、有效应对和预防任何公共卫生问题。目的:我们报告了在本报告所述期间,全国各地卫生机构向野口纪念医学研究所(NMIMR)提交的疑似甚高频临床标本用于诊断的情况。这在一定程度上是为了提供快速反应并提醒卫生系统预防疫情及其传播。方法:2017年1月至2018年12月,在全国卫生机构采集149例疑似vhf病例的临床血液标本,并将其送往国家预防和预防中心。采用实时逆转录聚合酶链反应对患者标本进行拉沙热、黄热病、登革热、基孔肯雅热、寨卡病毒、埃博拉病毒和马尔堡病毒病原体检测。然而,由于患者也表现出呼吸窘迫症状,对一个病例进行了流感检测。以结构化病例为基础的表格收集每个患者的人口统计和临床信息进行分析。结果:在检测的149份临床标本中,发现3份呈阳性,其中2份为登革热,1份为季节性甲型流感H1N1。对基于病例的表格的分析揭示了用于登记疑似病例的标准病例定义方面的缺陷。结论:我们的研究结果支持了对甚高频病毒进行常规监测活动的必要性,以尽量减少传播并可能预防暴发。此外,发热性疾病可由许多病原体引起,因此需要加强诊断以帮助患者管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Molecular detection of viral pathogens from suspected viral hemorrhagic fever patients in Ghana
Background: Viral hemorrhagic fevers (VHFs) are infectious illnesses that can cause serious morbidity and mortality to infected persons. During the 2014 Ebola virus disease outbreak in some West African countries, Ghana revamped its surveillance system across the country to prepare, effectively respond and pre-empt any public health concerns Objective: We report on suspected VHF clinical specimens submitted to the Noguchi Memorial Institute for Medical Research (NMIMR) from health facilities across the country for diagnosis within the period under review. This was partly to provide rapid response and to alert the health system to prevent outbreaks and its spread. Methods: From January 2017 to December 2018 clinical specimens of blood from 149 cases of suspected VHFs were collected at health facilities across the country and sent to NMIMR. Patient specimens were tested for viral pathogens including Lassa fever, Yellow fever, Dengue fever, Chikungunya, Zika, Ebola and Marburg by real-time reverse transcription-polymerase chain reaction. A case was however tested for influenza as the patient exhibited respiratory distress symptoms as well. Demographic and clinical information collected on a structured case-based forms were analyzed for each patient. Results: Out of the 149 clinical specimens tested, three (3) were found to be positive, with two (2) being Dengue and one (1) seasonal Influenza A H1N1. Analysis of the case-based forms revealed shortcomings with regards to standard case definitions used to enroll suspected cases. Conclusion: Our results buttress the need for a routine surveillance activity for VHFs to minimize spread and possibly forestall outbreaks. Moreover, febrile illnesses can be caused by a host of pathogens hence there is a need for enhanced diagnosis to help in patient management.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
期刊最新文献
Spontaneous pneumothorax in pregnancy: a case report and literature review A health surveillance data-based assessment of the impact of routine paediatric rotavirus vaccination on all-cause acute childhood diarrhoea Sleep quality and psychological well-being of university students Sexual and reproductive health communication between parents and adolescents: the case of Wa West District of the Upper West Region, Ghana Incidence and risk factors of steroid-induced ocular hypertension following pterygium excision with conjunctival autograft
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1