术前左室舒张功能不全患者手术心肌血运重建术后的不良事件

Sevleta Avdić, E. Osmanović, D. Mršić, N. Naser, N. Kadrić, Senada Husarić, A. Salihovic
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引用次数: 0

摘要

背景:大量接受手术心肌血运重建术(CABG)的患者有各种合并症,包括左室舒张功能障碍(LVDD)。目的:本文的目的是表明术前LVDD患者术后不良事件风险增加,预后较无LVDD患者差。方法:研究包括116例在图兹拉拜耳医学研究所接受心肌血运重建术(CABG)的患者,为期1年。这些患者之前都没有接受过CABG或瓣膜手术,也没有接受过支架植入(PCI)。超声心动图检查是否存在左室舒张功能障碍,将患者分为有和无LVDD两组,并进一步分为3个LVDD程度。结果:行手术心肌血运重建术未超声心动图检测到LVDD的患者占24.1%,有LVDD的患者占75.9%。LVDD组患者在重症监护病房(ICU)的天数明显高于无LVDD组患者。此外,LVDD患者的肌力支持小时数明显增加,心动过速(主要是房颤)的病例数明显增加。在这组患者中,观察到更多的其他不良事件,如心肌梗死,心脏或肾功能衰竭,TIA或CVI。在本研究的患者总数中,107例患者手术心肌血运重建术存活并恢复满意,9例(7.8%)存活,均来自LVDD组。结论:术前左心室舒张功能不全的患者,尤其是III级功能不全的患者,术后不良事件的风险更高,如房颤、在重症监护病房的住院时间延长、需要长期的肌力药物支持,且致命的结果仅记录在左室舒张功能不全的患者中。
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Adverse Events After Surgical Myocardial Revascularization in Patients With Preoperative Left Ventricular Diastolic Dysfunction
Background: A significant number of patients who underwent surgical myocardial revascularization (CABG) have various comorbidities, including left ventricular diastolic dysfunction (LVDD). Objective: The aim of this paper is to show that patients with preoperative LVDD are at an increased risk of postoperative adverse events and have a worse prognosis compared to patients without LVDD. Methods: The study included 116 patients who underwent myocardial revascularization (CABG) performed at Medical Institute Bayer in Tuzla over a period of 1 year. None of the patients had previously undergone CABG or valvular surgery, or undergone stent implantation (PCI). The presence of LV diastolic dysfunction was detected by echocardiography, and the patients were divided into two groups: with and without LVDD, and further classified into three degrees of LVDD. Results: Of the total number of subjects who underwent surgical revascularization of the myocardium without echocardiographically detected LVDD, 24.1% were patients, and 75.9% were patients with LVDD. In the group with LVDD, the range of days spent in the intensive care unit (ICU) is significantly higher compared to patients without LVDD. Also, patients with LVDD had a significantly higher number of hours of inotropic support, a significantly higher number of cases of tachycardia, predominantly atrial fibrillation (POAF). In this group of patients, a greater number of other adverse events were observed, such as myocardial infarction, cardiac or renal failure, TIA or CVI. Of the total number of patients in the study, 107 patients survived surgical myocardial revascularization and had a satisfactory recovery while 9 (7.8%) survived, all from the group with LVDD. Conclusion: Patients with preoperative diastolic dysfunction of the left ventricle, especially with III degree of dysfunction, are exposed to a higher postoperative risk of adverse events such as: atrial fibrillation, prolonged stay in the intensive care unit, the need for longer-term support with inotropes, and the fatal outcome was recorded exclusively in patients with LV diastolic dysfunction.
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