去甲肾上腺素、酚妥拉明和丁福地尔对仓鼠皮褶制剂中小动脉血管舒缩的影响。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158918
P H Carpentier
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引用次数: 1

摘要

血管舒缩是血管疾病药物的潜在靶点。本研究评价了去甲肾上腺素、酚妥拉明和血管活性药物丁福地尔在仓鼠皮褶制剂中对小动脉血管舒缩的影响。结果显示,去甲肾上腺素激活α -交感受体的血管动力学特性强,α -受体阻滞剂酚妥拉明有预期的抑制作用。丁咯地尔10(-4)M增强血管舒缩和小动脉反应性,不干扰去甲肾上腺素。丁咯地尔这些性质的作用机理还有待进一步研究。
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Norepinephrine, phentolamine and buflomedil influence on arteriolar vasomotion in the hamster skinfold preparation.

Vasomotion is a potential target for drugs in vascular diseases. In this work, the effects on arteriolar vasomotion of norepinephrine, phentolamine and the vasoactive drug buflomedil were assessed in the hamster skinfold preparation. Results show the strong vasokinetic properties of alpha-sympathetic receptor activation by norepinephrine and an expected depressive effect of the alpha-blocker phentolamine. Buflomedil 10(-4) M enhances vasomotion and arteriolar reactivity and does not interfere with norepinephrine. The mechanism of these properties of buflomedil remains to be investigated.

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Contractile and morphologic properties of a saphenous vein after 12 years as an aortocoronary bypass graft. Effect of H-8, an isoquinolinesulfonamide inhibitor of cyclic nucleotide-dependent protein kinase, on cAMP- and cGMP-mediated vasorelaxation. Hemorheological effects of buflomedil: action on shape and functions of the human neutrophils. Norepinephrine, phentolamine and buflomedil influence on arteriolar vasomotion in the hamster skinfold preparation. Heme-dependent activation of guanylate cyclase by nitric oxide: a novel signal transduction mechanism.
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