Uterine artery Doppler and Sub-Endometrial blood flow and Serum Progesterone level in patients with Unexplained Recurrent Miscarriage

Background : Unexplained miscarriage that occurs repeatedly is still a dif fi cult issue for couples and professionals. It affects 2 e 5% of females attempting to conceive and represents a considerable challenge for physicians. Aim : This study compares women who have unexplained recurrent miscarriages (RMs) with healthy, fertile women to assess uterine artery blood fl ow, subendometrial blood fl ow, and serum progesterone levels in these women. Patients and methods : The research was carried out at Al-Galaa Maternity Teaching Hospital; the patients were divided into two groups. The case group: 50 individuals disclosed a history of recurrent, unexplained miscarriages, and the control group: 50 individuals who had at least one term birth and no history of miscarriage. Results : The pulsatility index of the uterine artery especially the mean value, and fl ow index (FI), vascular index, and vascular FI of the endometrial and subendometrial area, in addition to the serum progesterone level are crucial factors in case of unexplained RM. They affect unexplained RM incidence signi fi cantly. The pulsatility index of the uterine artery has an in fl uence on unexplained RM with 74% accuracy. The FI has 95% accuracy, and the vascular FI has 86% accuracy in case of unexplained RM. The serum progesterone level has a 70% accuracy effect on unexplained RM. Conclusion : The study documented that the uterine artery Doppler, endometrial and subendometrial blood fl ow level, and serum progesterone level affect the incidence of unexplained RM with accuracy ranging between 70 and 95%.