一氧化氮对鸟苷酸环化酶血红素依赖性的激活:一种新的信号转导机制。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158845
L J Ignarro
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引用次数: 105

摘要

细胞内合成的一氧化氮(NO)与邻近靶细胞内的胞质鸟苷酸环化酶结合的血红素相互作用,产生鸟苷酸环化酶的NO-血红素加合物,这是一种新的广泛的信号转导机制,将细胞外刺激与靶细胞内环GMP的生物合成联系起来。多种化学因子与选择性细胞外受体相互作用,触发l -精氨酸生物合成NO。一氧化氮独特的化学性质赋予了这种分子迅速扩散到附近细胞并刺激环状GMP形成的能力。环GMP在每种细胞类型中作为信使,在局部环境中触发不同但互补的细胞反应。这种跨细胞信号是一种快速的细胞间通讯形式,允许同时局部启动增加血流量,抑制血小板诱导的血栓形成和其他细胞功能。
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Heme-dependent activation of guanylate cyclase by nitric oxide: a novel signal transduction mechanism.

The interaction between nitric oxide (NO) synthesized in one cell and cytosolic guanylate-cyclase-bound heme located in adjacent target cells to generate the NO-heme adduct of guanylate cyclase represents a novel and widespread signal transduction mechanism that links extracellular stimuli to the biosynthesis of cyclic GMP in target cells. A variety of chemical factors interact with selective extracellular receptors and trigger the biosynthesis of NO from L-arginine. The unique chemistry of NO endows this molecule with the capacity to diffuse rapidly into nearby cells and stimulate cyclic GMP formation. Cyclic GMP acts as a messenger in each cell type to trigger different but complementary cellular responses within a localized environment. This transcellular signaling is a form of rapid intercellular communication allowing the simultaneous local initiation of increased blood flow, inhibition of platelet-induced thrombosis and other cellular functions.

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