Frequency of non-responders of statins in acute coronary syndrome patients

BACKGROUND: Acute coronary syndromes (ACS) includes non ST elevation (NSTEMI) or ST elevation myocardial infarction (STEMI) along with unstable angina and is associated with high morbidity and mortality despite advances in treatment. Statins is one of the pharmacological agent in the management of acute coronary syndrome (ACS). After remarkable advances in medical management over many years, a significant proportion of patients still do not respond to Statins.   AIMS; OBJECTIVE: To assess the frequency of non-responders of statins in acute coronary syndrome patients METHODOLOGY: This cross-sectional study was carried-out at Punjab Institute of Cardiology, Lahore (PIC) from August 10, 2015 to February 10, 2016. Total 325 patients who fulfilled the inclusion criteria were enrolled and counseled about the details of the study. After taking consent, detailed history and examination was recorded. Details were recorded regarding age, gender of the patient. All patients received 10mg of rosuvastatin. Data stratification was done for age, gender and duration of ACS. Chi-square test was used after stratification to check the significance. p-value was taken as significant when less than 0.05. CONCLUSION: There is a significant number of patients with no response to statins. Lipid-lowering statin regimen gives individuals who have recently experienced ACS increased protection against mortality or experiencing serious cardiovascular events. Results show that such patients benefit from early and ongoing LDL cholesterol reduction