大鼠离体十二指肠的自发机电活动。

A Postorino, R Mancinelli, C Racanicchi, E B Adamo, R Marini
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引用次数: 15

摘要

离体大鼠十二指肠显示自发的机械和电活动。机械活动包括腔内压力和等距张力的变化。电活动的特点是慢波叠加爆发。这种自发活动是河豚毒素(TTX)抗性的,因此它起源于肌源性。事实上,TTX预处理,即使在阿托品和胍乙啶存在的情况下,也会引起电和机械活动的幅度和频率的增加。这一发现表明存在强直活性抑制壁内非肾上腺素能、非胆碱能(NANC)神经。十二指肠纵条显示与分离节段相似的自发机械活动。相反,在静息状态下,圆形条带处于静止状态,只有经过TTX预处理后才能检测到收缩活动,这表明:1)圆形平滑肌层受到壁内NANC神经的强直抑制;2)大鼠十二指肠的收缩是由于纵向神经的活动引起的。
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Spontaneous electromechanical activity in the rat duodenum in vitro.

Isolated rat duodenum shows spontaneous mechanical and electrical activities. Mechanical activity consists in changes both in endoluminal pressure and in isometric tension. Electrical activity is characterized by slow waves with superimposed bursts. This spontaneous activity is tetrodotoxin (TTX) resistant and therefore it is myogenic in origin. Indeed, TTX pretreatment, even in the presence of atropine and guanethidine, caused an increase in amplitude and in frequency of the electrical and mechanical activities. This finding indicates the presence of tonically active inhibitory intramural non adrenergic, non cholinergic (NANC) nerves. Duodenal longitudinal strips showed a spontaneous mechanical activity resembling that one recorded from isolated segment. Instead, circular strips are quiescent under resting condition and a contractile activity can be detected only after TTX pretreatment suggesting that: i) the circular smooth muscle layer is tonically inhibited by intramural NANC nerves and, ii) the contractions observed in the rat duodenum are due to the activity of the longitudinal one.

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