用一个细胞创造出一个完整的器官

Sylvain Cussat-Blanc, H. Luga, Y. Duthen
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引用次数: 3

摘要

本文展示了我们人工胚胎发生模型的最新结果(Cussat-Blanc et al., 2007)。在自然界中,细胞能够专门化它们的功能。这种专门化允许创建具有相同功能的细胞群,通常称为组织。为了执行特定的动作,组织被归类为器官。细胞特化发生在生物体发育的不同阶段。这种专门化的内部编码在DNA分子中,作为一个基因调控网络,并在生长过程中受到胎儿周围不同蛋白质的调节。在我们的项目中,我们希望使用不同层次的细节来模拟这种专门化。本文提出了一个忘记化学和物理的复杂性而关注细胞机制的复杂性的模型。使用这个模型,我们想要生成像《模拟人生》(1994)那样的人造生物。
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Using a single cell to create an entire organ
This paper shows the latest results of our artificial embryogeny model (Cussat-Blanc et al., 2007). In nature, cells are able to specialize their functions. This specialization allows the creation of cells groups that perform the same function, commonly named tissues. To perform a specific action, tissues are grouped in organs. The cell specialization happens at different stages in the organism's development. The internals of this specialization is coded in the DNA molecule as a gene regulatory network and regulated during the growth with different proteins contained in the foetus neighborhood. In our project, we want to simulate this specialization using different levels of detail. This paper presents a model that forgets the complexity of chemistry and physics to focus on the complexity of cell's mechanisms. Using this model, we want to generate artificial creature like Sims' ones (1994).
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