视觉诱发电位法客观评价视敏度及其成熟度的试验

L Marechal, J Faidherbe
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引用次数: 0

摘要

我们开发了一种通过分析vep来估计中央凹视力(VA)的方法。它包括在模式反转中确定最小的检查大小,从而引起显著的皮层反应。如果p100振幅达到信噪比中预先设定的水平,则VEP被认为是显著的。从84只准屈光眼和屈光眼的测试中得出了一个确定正常VEP- va的有效标准:在我们的刺激和记录条件下,对7分钟检查的反转有显著的VEP反应对应于正常的中央凹敏锐度。该标准也被证明适用于区分正常VAs为20/20和降低VAs(20/40或以下)的其他四组受试者:14只成人眼睛,其VAs为20/20通过Bangerter闭塞降低,32只属于5岁儿童,28只属于12岁儿童的屈光不正和屈光不正。为了保证结果的有效性,我们与眼科医生进行了双盲研究。我们建议的方法的相关性与外推VEP振幅和模式元素大小之间的回归线的方法有关。至少我们的目标是建立eva成熟的VEP规范。我们收集了以下受试者的数据:每月测试1至6个月的5名婴儿,1至16个月的31名婴儿,10名5岁儿童,13名12岁儿童和11名20岁的受试者。在我们的刺激和记录条件下,从8个月后可以观察到对7分钟检查的逆转的显著诱发反应。对于一个8个月大的婴儿来说,这种对7分钟检查的逆转的反应与成年人的反应是不同的。两者有两个主要区别:主要积极成分的潜伏期更长,诱发反应的结构由较少的成分组成。
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[Trial on the objective evaluation of visual acuity and its maturation by the method of evoked visual potentials].

We have developed a method to estimate foveal visual acuity (VA) through analysis of VEPs. It consists in determining the smallest check size in a pattern reversal that elicits a significant cortical response. The VEP is regarded as significant if the P 100 amplitude reaches a pre-established level in the signal to noise ratio. A valid criterion to determine normal VEP-VA emerges from the testing of 84 emmetropic and ametropic eyes: within our stimulation and recording conditions, a significant VEP response to the reversal of seven minutes checks corresponds to normal foveal acuity. This criterion has also proved pertinent to discriminate between normal VAs of 20/20 and decreased VAs (20/40 or less) with four other groups of subjects: 14 adult eyes whose VAs of 20/20 are decreased through Bangerter occlusives, 32 emmetropic and ametropic eyes belonging to five-years-olds children, 28 emmetropic and ametropic eyes of twelve-years-olds. In order to guarantee the validity of our results we carried out a double-blind study with ophthalmologists. The relevance of the method we suggest is related to that of the method which consists in extrapolating the regression line between VEP amplitudes and the pattern element sizes. At least we have aimed at establishing VEP norms for the maturation of VA. We have collected data from the following subjects: 5 infants tested monthly between 1 and 6 months, 31 infants ranging in age from 1 to 16 months, 10 five-year-old children, 13 twelve-year-olds, and 11 subjects aged 20. Within our stimulation and recording conditions a significant evoked response to the reversal of seven minute checks can be observed from 8 months onward. With an eight-month-old infant this response to the reversal of seven minute checks cannot be identified to the same response with an adult. There are two major differences: the latency of the major positive component is longer, and the structure of the evoked response consists of fewer components.

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