1,2,4-三唑类衍生物的合成研究综述

R. Omer, Rzgar Farooq Rashid, Khdir A. Othman
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摘要

三唑类衍生物的药理活性已被研究者广泛研究。三唑的不同衍生物在治疗各种疾病方面显示出希望。大多数三唑衍生物具有抗炎、抗癌、抗菌和抗真菌活性。这些化合物调节各种生物过程的能力使它们对药物开发具有吸引力。此外,三唑的低成本和广泛可用性使它们对药物开发更具吸引力。除了药理活性外,三唑衍生物还具有抗氧化特性。研究表明,1,2,3-三唑具有抗氧化损伤和抑制脂质过氧化的作用。此外,1,2,4-三唑还具有抗氧化和清除自由基的作用。三唑类化合物的抗氧化性能使其成为开发新药的热点。三唑类衍生物的合成也得到了广泛的研究。合成三唑衍生物的方法多种多样,包括化学方法和酶法。化学方法包括通过烷基卤化物与叠氮化物的反应形成环状结构。酶促法涉及使用。
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Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review
The pharmacological activities of triazole derivatives have been studied extensively by researchers. Different derivatives of triazole have showed promise in treating various diseases. Most triazole derivatives have demonstrated anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal activities. The ability of these compounds to modulate various biological processes has made them attractive for pharmaceutical development. Furthermore, the low cost and wide availability of triazoles have made them even more attractive for drug development. In addition to the pharmacological activities, triazole derivatives have also been reported to possess antioxidant properties. Studies have shown that 1,2,3-triazole can protect against oxidative damage and inhibit lipid peroxidation. Furthermore, 1,2,4-triazole has been found to act as an antioxidant and scavenge free radicals. The antioxidant properties of triazoles make them attractive for the development of new drugs. The synthesis of triazole derivatives has also been studied extensively. Various methods have been developed to synthesize triazole derivatives, including chemical and enzymatic methods. Chemical methods involve the formation of cyclic structures by the reaction of alkyl halides with azides. Enzymatic methods involve the use.
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