各种恶性肿瘤患者血清免疫反应性胰磷脂酶A2的变化。

Enzyme Pub Date : 1990-01-01 DOI:10.1159/000468710

Y Oka, M Ogawa, Y Matsuda, A Murata, J Nishijima, K Miyauchi, K Uda, T Yasuda, T Mori

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引用次数: 17

摘要

血清胰磷脂酶A2 (PLA2)升高在各种恶性肿瘤患者中发生率高(40.6%)。与性别和年龄匹配的健康献血者相比，癌症患者血清PLA2显著升高(358.4 +/- 168.0对241.7 +/- 69.0 ng/dl;P < 0.01)。这些患者血清PLA2与癌胚抗原(CEA)无相关性。晚期及远处转移性肝癌、胆囊癌和胰腺癌患者血清PLA2水平高于早期癌症患者，而其他癌症患者血清PLA2水平与临床分期无相关性。PLA2和CEA联合检测将癌症检测的敏感性提高到60.8%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Serum immunoreactive pancreatic phospholipase A2 in patients with various malignant tumors.

The high incidence (40.6%) of elevated serum pancreatic phospholipase A2 (PLA2) was demonstrated in patients with various malignancies. Serum PLA2 was significantly increased in cancer patients compared with healthy sex- and age-matched blood donors (358.4 +/- 168.0 vs. 241.7 +/- 69.0 ng/dl; p less than 0.01). No correlation was observed between serum PLA2 and carcinoembryonic antigen (CEA) in these patients. Although patients with advanced and distantly metastatic cancer of the liver, gallbladder and pancreas showed higher PLA2 levels in serum than those with early cancer, patients with other cancers showed no correlation between serum PLA2 and clinical stage. A combined assay of PLA2 and CEA increased the sensitivity of detection of cancers to 60.8%.

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