多层生物网络中簇的结构分析

R. Mittal, M. Bhatia
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引用次数: 2

摘要

现在,许多生物学问题都以网络的形式被组织起来,称为生物网络。这种大型网络的形成有助于我们广泛有效地分析生物系统。尽管生物网络的大小和结构非常复杂,如果不进行进一步的处理,很难对这些网络进行解释。本文讨论了通过形成集群来分析这类系统,并利用网络中形成的不同类型的集群来分析整个系统的排列。聚类是网络中高度连接的一组节点,聚类分析是用于分析生物系统的突出特征之一。在这里,我们通过在多层生物网络上应用一些流行的聚类算法来展示我们的研究,以观察当包含生物实体之间的多种相互作用以及此类网络中对象的行为时,聚类的形状,大小和结构的变化。
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Analyzing the Structures of Clusters in Multi-layer Biological Networks
Nowadays many biological problems are structured in the form of networks called biological networks. Formation of such large networks helps us in analyzing biological systems extensively and effectively. Although the size and structure of biological networks are very complex and it is difficult to interpret such networks without further processing. In this paper, we discuss the analysis of such systems by forming clusters and analyze the whole arrangement using different types of clusters formed in the network. A cluster is a highly connected group of nodes of the net and cluster analysis is one of the prominent features used for the analysis of the biological systems. Here, we present our study by applying some popular clustering algorithms on multi-layer biological networks to see the changes in the shape, size, and structure of the clusters when multiple interactions among biological entities are included and the behavior of objects in such networks.
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