T. Calogeropoulou, George E. Magoulas, Ina Pöhner, R. Wade, Joanna Panecka-Hofman, Pasquale, Linciano, S. Ferrari, Maria Paola Costi, N. Santarém, Ma., Dolores M. Jiménez‐Antón, A. I. Olías-Molero, Anabela, C. Silva, J. M. Alunda
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引用次数: 2
摘要
被忽视的热带病(NTDs)是世界卫生组织(WHO)承认的一组17种病症，在全球149个热带和亚热带地区国家流行，总体影响超过10亿人(Feasey et al. 2010)。这些疾病都是由微寄生虫或大寄生虫引起的。在微寄生虫引起的疾病中，有三种是由由昆虫媒介传播的一组鞭毛原虫——动质体科引起的:恰加斯病、非洲人类锥虫病和利什曼病。本章的重点是鉴定治疗锥虫病感染的新药，如由克氏锥虫引起的恰加斯病和由布鲁氏锥虫引起的非洲人类锥虫病(Filardy et al. 2018)。
Hits and Lead Discovery in the Identification of New Drugs against the Trypanosomatidic Infections
The Neglected Tropical Diseases (NTDs) are a group of 17 pathologies, recognized by the World Health Organization (WHO), which are endemic in 149 countries of tropical and sub-tropical areas of the globe, and affect more than one billion people overall (Feasey et al. 2010). The pathologies are all caused by microparasites or macroparasites. Among the diseases provoked by microparasites, three are caused by kinetoplastidae, a group of flagellated protozoa transmitted by insect vectors: Chagas disease, Human African Trypanosomiasis and leishmaniasis. The focus of the present chapter is on the identification of new drugs for the treatment of trypanosomatidic infections such as Chagas disease, caused by Trypanosoma cruzi, and Human African Trypanosomiasis, caused by Trypanosoma brucei (Filardy et al. 2018).
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