{"title":"定量蛋白质组学方法在毒理学中的应用","authors":"T. Prasad, R. Chaerkady","doi":"10.1002/9780470744307.GAT214","DOIUrl":null,"url":null,"abstract":"Epidemiological and genetic studies have significantly contributed to our understanding of hazardous effects of various environmental pollutants on biological systems at a molecular level. However, only limited reports exist those describe proteomic alterations associated with toxicity of such pollutants. Proteomic signatures can be employed as biomarkers for exposure as well as toxicity. Improved protein/peptide labeling technologies have led to the development of a variety of methodologies for quantitative proteomics that can be used to obtain differential protein profiles. This review highlights various quantitative proteomic technologies, which can be applied to unravel proteomic changes in response to toxicants. \n \n \nKeywords: \n \nbiomarkers; \nclinical proteomics; \niTRAQ; \nArsenic; \nmass spectrometry; \nsignaling pathways","PeriodicalId":325382,"journal":{"name":"General, Applied and Systems Toxicology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of Quantitative Proteomic Approaches to Toxicology\",\"authors\":\"T. Prasad, R. Chaerkady\",\"doi\":\"10.1002/9780470744307.GAT214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Epidemiological and genetic studies have significantly contributed to our understanding of hazardous effects of various environmental pollutants on biological systems at a molecular level. However, only limited reports exist those describe proteomic alterations associated with toxicity of such pollutants. Proteomic signatures can be employed as biomarkers for exposure as well as toxicity. Improved protein/peptide labeling technologies have led to the development of a variety of methodologies for quantitative proteomics that can be used to obtain differential protein profiles. This review highlights various quantitative proteomic technologies, which can be applied to unravel proteomic changes in response to toxicants. \\n \\n \\nKeywords: \\n \\nbiomarkers; \\nclinical proteomics; \\niTRAQ; \\nArsenic; \\nmass spectrometry; \\nsignaling pathways\",\"PeriodicalId\":325382,\"journal\":{\"name\":\"General, Applied and Systems Toxicology\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"General, Applied and Systems Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/9780470744307.GAT214\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"General, Applied and Systems Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/9780470744307.GAT214","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Application of Quantitative Proteomic Approaches to Toxicology
Epidemiological and genetic studies have significantly contributed to our understanding of hazardous effects of various environmental pollutants on biological systems at a molecular level. However, only limited reports exist those describe proteomic alterations associated with toxicity of such pollutants. Proteomic signatures can be employed as biomarkers for exposure as well as toxicity. Improved protein/peptide labeling technologies have led to the development of a variety of methodologies for quantitative proteomics that can be used to obtain differential protein profiles. This review highlights various quantitative proteomic technologies, which can be applied to unravel proteomic changes in response to toxicants.
Keywords:
biomarkers;
clinical proteomics;
iTRAQ;
Arsenic;
mass spectrometry;
signaling pathways
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