评价白血病和实体瘤的难民儿童在土耳其:三级中心经验

Ayça Koca Yozgat, Derya Özyörük, S. Emir, A. Demir, Arzu Yazal Erdem, C. B. Aker, Zeliha Güzelküçük, İnci Yaman Bajin, D. Kaçar, N. Yaralı, N. Özbek
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摘要

癌症治疗逐渐成为一项全球性的重大挑战。战争可能造成破坏,并延误流离失所者的癌症诊断和治疗。癌症治愈率需要在难民等无法抵抗的人群中得到提高。在这项研究中,我们的目的是强调临床特点和结果难民儿童癌症在我们医院。我们的目的是展示我们的发现,并为改善这些儿童的医疗保健做出贡献。2011年4月至2019年1月期间在我院肿瘤科和血液科住院的71名难民儿科患者被纳入本研究。从患者档案中回顾性分析患者初诊时的人口学特征、原籍国、生活条件、组织病理学诊断、治疗、复发和死亡率数据。患者中位年龄为6.5±4.5岁,男女比例为39/32。44例(61.9%)患者有主诉,在我院进行了初步诊断,其余27例(38.1%)患者在本国确诊,并申请到我院治疗。平均随访时间为18.2±18.8个月(1 ~ 90个月)。结果,44例(62%)患者存活,22例(31%)患者死亡。第二年无复发生存率为83.6%。2年和5年生存率分别为77.5%和58.1%。与土耳其儿童相比,难民儿童的存活率较低。除了肿瘤类型和分期等癌症特定因素外,住所、沟通、坚持治疗和药品供应困难等问题可能是难民儿童存活率较低的原因。需要进一步的研究来提高患者的存活率。
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Evaluation of Leukemia and Solid Tumors in Refugee Children in Turkey: A Tertiary Center Experience
Cancer care is progressively became as a significant worldwide challenge. Wars can cause destructions and delays in cancer diagnosis and treatment of displaced people. Cancer cure rates need to be improved in indefensible populations such as refugees. In this study, we purposed to highlight the clinical peculiarities and outcomes of refugee children with cancer in our hospital. Our purpose was to present our findings and contribute to improve the health care for these children. Seventy one refugee pediatric patients admitted to the oncology and hematology units of our hospital between April 2011 and January 2019 were included in this study. The demographic characteristics of the patients at the initial diagnosis, their countries of origin, living conditions, histopathological diagnoses, treatments, relapse, and mortality data were analyzed retrospectively from the patient files. The median age of patients was 6.5±4.5 years, and the male-to-female ratio was 39/32. While 44 patients (61.9%) presented with complaints and had primary diagnoses in our hospital, the remaining 27 patients (38.1%) were diagnosed in their country and applied to our hospital for treatment. Our mean follow-up period was 18.2±18.8 months (1-90 months). As a result, 44 patients (62%) were alive and 22 (31%) were dead. The survival rate without relapse in the second year was 83.6%. Two and fiveyear survival rates were 77.5% vs. 58.1% respectively. Compared to Turkish children, lower survival rates were found in refugee children. In addition to cancer-specific factors such as tumor type and stage, some problems such as shelter, communication, adherence to treatment, and difficulties supplying medicine may be responsible for lower survival rates in refugee children. Further studies are needed to improve the survival rates of patients.
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