立体控制合成psi[CH = CH]二肽同工异构体。

D J Kempf, X C Wang, S G Spanton
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引用次数: 0

摘要

介绍了一种新的立体控制合成psi[CH = CH]二肽同工异构体的方法。该序列的关键步骤依赖于δ -氨基- γ -甲氧基- α, β -不饱和酯的立体特异性烷基化。通过这种方法,亲核侧链的广泛可用性允许制备各种具有可预测立体化学性质的psi[CH = CH]同分异构体。
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Stereocontrolled synthesis of psi[CH = CH] dipeptide isosteres.

A new stereocontrolled synthesis of the psi[CH = CH] dipeptide isostere is described. They key step of the sequence relies on the stereospecific alpha-alkylation of delta-amino-gamma-mesyloxy-alpha,beta-unsaturated esters. The broad availability of nucleophilic alpha-side chains by this method allows the preparation of a wide variety of psi[CH = CH] isosteres with predictable stereochemistry.

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