紧张症:卡马西平开放前瞻性系列。

P. R. Kritzinger, G. Jordaan
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引用次数: 47

摘要

鉴于文献报道苯二氮卓类药物对紧张症反应良好,以及紧张症与癫痫性疾病之间可能存在的关联,我们开展了一项开放的前瞻性研究,探讨卡马西平成功治疗紧张症的可能性。符合DSM-IV紧张症标准的患者接受劳拉西泮IMI治疗并评估其反应。对卡马西平无反应、部分反应和症状复发的患者进行了卡马西平试验,并评估了他们的反应。我们对9名患者进行了评估。9人中有6人对劳拉西泮有完全但短暂的反应。所有患者均给予卡马西平试验:4例紧张症状完全缓解,1例部分缓解,4例无明显改善。卡马西平似乎是一个有效的治疗,无论是在急性期,并作为一个亚组的弱智紧张性精神病患者的维持。
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Catatonia: an open prospective series with carbamazepine.
In view of reports in the literature that catatonia responds well to benzodiazepines, and the possible association between catatonia and seizure disorders, an open prospective study was conducted to explore the possibility that catatonia may be successfully treated with carbamazepine. Patients meeting DSM-IV criteria for catatonia were challenged with lorazepam IMI and their response assessed. Non-responders, partial responders and patients who had a recurrence of symptoms were put on a trial of carbamazepine and their response assessed. Nine patients were assessed at our unit. Six of the 9 had a complete, but transient response to lorazepam. All of the patients were given a trial of carbamazepine: 4 had a complete resolution of catatonic symptoms, 1 had a partial resolution and 4 patients did not show a significant improvement. Carbamazepine seems to be an effective treatment, both in the acute phase, and as maintenance in a subgroup of retarded catatonic patients.
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