卡维地洛的电化学特性及基于氧化锌纳米颗粒的简易传感器在片剂中含量测定中的应用

E. Güven, F. Öztürk
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引用次数: 0

摘要

在Britton Robinson缓冲液中,采用循环伏安法和方波伏安法测定了卡维地洛在pH为8.0的氧化锌纳米颗粒碳糊电极上的电化学特性。计算了分子在修饰电极上的吸附特性和电极反应的电子数。此外,还提出了一种新的方波阳极吸附溶出伏安法测定卡维地洛药物样品的方法。该工艺的线性浓度范围为0.07µM ~ 2.61µM,检出限为0.09µM。对药物样品中的CAR进行了回收研究,以检查所开发过程的准确性。该方法具有较高的可靠性、重复性、准确度和精密度,可用于药品样品中CAR的测定。
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Electrochemical characteristics of Carvedilol and Its Application of simple Sensor Based on zinc oxide nanoparticles for the Determination in Tablet
In the study, the electrochemical characteristics of carvedilol were determined by cyclic voltammetry and square wave voltammetry on carbon paste electrode with zinc oxide nanoparticles at pH 8.0 in Britton Robinson buffer. The adsorption characteristics of the molecule on the modified electrode and the electron number accompanying the electrode reaction were calculated. In addition, a new square wave anodic adsorptive stripping voltammetry process was suggested for the determination of carvedilol drug samples. The linear concentration range and detection limit of the process were found to be 0.07 µM–2.61 µM and 0.09 µM, respectively. Recovery studies of CAR in the pharmaceutical sample were performed to check the accuracy of the developed process. With the developed process, results with high reliability, reproduceability, accuracy and precision were obtained for the determination of CAR in pharmaceutical samples.
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