Frans J.M. van Breukelen , Karin Mattson , Giuseppe Giaccone , Nico van Zandwijk , Hans T. Planteydt , Anne Kirkpatrick , Otilia Dalesio
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Mitoxantrone in malignant pleural mesothelioma: A study by the EORTC lung cancer cooperative group
46 patients with malignant pleural mesothelioma were entered in a phase II study of mitoxantrone 14 mg/m2 every 3 weeks. Histology was confirmed by a pathology panel. None of the patients had received previous chemotherapy. Toxicity was mainly mild gastrointestinal and haematological side-effects. Out of 34 patients evaluated for response, only 1 partial response was recorded. Mitoxantrone at this dose and schedule has marginal activity in malignant mesothelioma.
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