慢性卡托普利治疗可逆转自发性高血压大鼠血管中3-甲基组氨酸浓度的升高。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158889
J R Jonsson, D B Frewin, R J Head
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引用次数: 2

摘要

对自发性高血压大鼠血管的形态计量学研究提供了证据,表明内侧肥大是高血压血管变化的一个关键特征。在本研究中,我们确定了3-甲基组氨酸(3MH),一种翻译后修饰的氨基酸,在肌肉的肌动蛋白和肌球蛋白中发现,是否可以提供这种变化的生化标记。我们的结果表明,与Wistar-Kyoto大鼠血管组织中的浓度相比,自发性高血压大鼠血管中的3MH浓度有选择性地升高。两菌株非维管组织中3MH浓度相近。慢性卡托普利治疗可预防自发性高血压大鼠高血压的发展,并与血管3MH浓度的降低有关。因此,我们认为3MH血管浓度是反映自发性高血压大鼠高血压发展过程中血管平滑肌收缩蛋白变化的一个有用的生化指标。
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Chronic captopril treatment reverses the enhanced vascular concentrations of 3-methylhistidine in the spontaneously hypertensive rat.

Morphometric studies conducted on the blood vessels of the spontaneously hypertensive rat have provided evidence that medial hypertrophy is a key characteristic of the vascular change which occurs in hypertension. In the present study, we determined whether 3-methylhistidine (3MH), a post-translationally modified amino acid which is found uniquely in the actin and myosin of muscle, could provide a biochemical marker of such change. Our results indicated that the concentrations of 3MH were selectively elevated in the blood vessels from the spontaneously hypertensive rat, when compared with concentrations in vascular tissues from the Wistar-Kyoto rat. The concentrations of 3MH in non-vascular tissues were similar in the two strains. Chronic captopril treatment prevented the development of hypertension in the spontaneously hypertensive rat and was associated with a reduction of the vascular concentrations of 3MH. We therefore conclude that blood vessel concentrations of 3MH are a useful biochemical index of the changes in vascular smooth muscle contractile protein which occur during the development of hypertension in the spontaneously hypertensive rat.

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