一种金纳米颗粒与羟基富勒烯水配合物作为化妆品的新产品

R. Rudolf, Ž. Jelen, M. Zadravec, P. Majerič, Z. Jović, M. Vuksanović, I. Stanković, L. Matija, A. Dragicevic, N. Miso Thompson, A. Horvat, D. Koruga
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引用次数: 4

摘要

以金(III)氯化(AuCl3)和金(III)乙酸(AuC6H12O6)水溶液为原料,初始浓度为Au 0.5 g/L,利用超声喷雾热解(USP)装置合成了3种金纳米颗粒(AuNPs)。在去离子水(D.I.)的悬浮液中收集AuNPs,加入稳定剂聚乙烯吡咯烷酮(PVP)或聚乙二醇(PEG),然后将AuNPs冷冻干燥,作为乳霜的新添加剂。以标准乳膏基质为基质,制备了三种具有相同浓度比的AuNPs乳膏。第三种AuNPs乳膏采用专利的羟基化富勒烯水络合物(3HFWC-W)基质制备。为了检验AuNPs作为面霜添加剂的效果,研究人员对33名没有皮肤病的志愿者进行了为期6周的面霜试验。在研究期间,测量皮肤的三个主要参数:胶原蛋白质量,皮肤保湿和表皮-真皮层功能。研究结果发现,由于在标准面霜中使用了AuNPs,胶原蛋白质量的改善在18- 24%之间,而3HFWC-W和AuNPs联合使用的面霜的改善幅度明显更高,达到45.7%。研究还发现,在含有AuNPs的标准面霜中,皮肤的水合作用(角质层)增加了6.4- 9.6%,而在含有3HFWC/AuNPs的面霜中,这一比例为73.7%。表皮-真皮功能也得到了类似的结果,其中含有AuNPs的标准面霜改善了24- 28%,3HFWC-W/AuNPs的面霜改善了38.4%。
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A gold nanoparticles and hydroxylated fullerene water complex as a new product for cosmetics
Three types of gold nanoparticles (AuNPs) were synthesised with a custom-made Ultrasonic Spray Pyrolysis (USP) device, from aqueous solutions of gold (III) chloride (AuCl3) and gold (III) acetate (AuC6H12O6), with an initial concentration of Au 0.5 g/L. AuNPs were collected in suspensions of deionised (D.I.) water with the stabilisers polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG), followed by the process of freeze drying the AuNPs to be useful as a new additive for the cream. The standard cream base was used as a matrix for preparation of three types of cream with AuNPs in the same concentration ratios. The third AuNPs cream was prepared with a patented hydroxylated fullerene water complex (3HFWC-W) matrix. To examine the effect of AuNPs as additive in creams, a six-week study of test creams was conducted on 33 volunteers with no dermatological diseases. During the study three main parameters of the skin where measured: Collagen quality, skin moisturisation and the epidermis-dermis function. The results of the study found improvements of collagen quality between 18-24 %, achieved due to the use of AuNPs in standard creams, while the cream with the combination of 3HFWC-W and AuNPs gave significantly higher improvements with a value of 45.7 %. It was also discovered that hydration of the skin (stratum cornum) increased by 6.4-9.6 % in standard creams with AuNPs, and 73.7 % in the 3HFWC/AuNPs` cream. Similar results were measured by the epidermis-dermis function, where 24-28 % improvement for standard creams with AuNPs was identified, and 38.4 % for the cream 3HFWC-W/AuNPs.
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