数字载玻片的倍性分析

V. Jonas, M. Kozlovszky, B. Molnár
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引用次数: 6

摘要

数字成像和图像处理在某些医学领域都在迅速发展。病理学就是其中一个领域。数字载玻片是至少从19世纪50年代开始用于病理学的老式玻璃载玻片的数字化版本。就诊断的可重复性、存储和(远程)咨询的可能性而言,这些数字幻灯片可能是病理学不久的将来。本文针对样品中DNA含量的测定。这一测量的意义在于,在某一特定时刻,活人体内处于有丝分裂阶段(即繁殖阶段)的细胞比例是健康的。增加的比例是癌症的标志。因此,比值与肿瘤侵袭程度成正比。快速生长的肿瘤区域由快速繁殖的细胞组成,因此与健康组织相比,一次繁殖的细胞更多。这种测量方法可以用来判断相关组织(和患者)是健康的还是患有癌症。甚至有可能从生长的侵袭性判断癌症的类型或治疗的紧迫性。
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Ploidy analysis on digital slides
Both digital imaging, and image processing in certain areas of medical sciences is evolving quickly nowadays. Pathology is one of these fields. A digital slide is the digitized version of the good old glass slides used in pathology at least from the 1850s. These digital slides are possibly the near future of pathology in terms of repeatability of diagnosis, storage, and possibility of (tele)consultation. This paper targets the measurement of DNA content in the specimen. The significance of this measurement is, that there is a healthy ratio of cells being in the phase of mitosis (i.e. the phase of reproduction), in a living person, at a given moment. The increased ratio is a cancer marker. Consequently, the ratio is proportional to the tumor aggressivity level. Quickly growing tumor areas consist of quickly reproducing cells, so at a time more cells are reproducing, than in a healthy tissue. This measurement can probably be used to decide if the tissue (and patient) in question is healthy or has cancer. It is even possible that from the aggressivity of growth the type of cancer or the urgency of treatment can be presumed.
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