α干扰素治疗原发性血小板增多症和其他骨髓增生性疾病伴血小板增多症

Xenophon Yataganas, John Meletis, Eleni Plata, Nora Viniou, Filippos Deligiannis, Christina Tsekoura, Ersi Voscaridou, Viki Boussiotis, John Rombos, Georges Vayopoulos, Christos Kittas, Phaedon Fessas
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引用次数: 11

摘要

研究了重组干扰素α -2b对18例骨髓增生性疾病及相关血小板增多症患者(原发性血小板增多症9例,真性红细胞增多症3例,骨髓纤维化3例,慢性骨髓性白血病3例)血小板计数、血小板增多症相关症状及骨髓纤维化的影响。94%的患者在治疗后8 - 330天内血小板计数降至600 × 109/L以下,77%的患者降至400 × 109/L以下。在大多数患者中,α干扰素的选择性血小板减少作用维持了很长一段时间,没有严重的副作用。血小板数量减少到接近正常水平后,血小板增多相关症状得到缓解。在研究的七名患者中,有两名患者在治疗后发现骨髓网状蛋白含量降低。干扰素的副作用是流感样症状,通常在治疗7天内消退。
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Alpha interferon treatment of essential thrombocythaemia and other myeloproliferative disorders with excessive thrombocytosis

The effect of recombinant interferon alfa-2b on platelet count, thrombocytosis-associated symptoms and marrow fibrosis was studied in 18 patients with myeloproliferative diseases and associated thrombocytosis (nine with essential thrombocythaemia, three with polycythaemia vera, three with myelofibrosis and three with chronic myelogenous leukaemia). A reduction of the platelet count below 600 × 109/L was achieved in 94%, and below 400 × 109/L in 77% of the patients within 8 to 330 days of treatment. The selective thrombocytosis-reducing effect of alpha interferon was maintained for long periods of time in most patients without serious side effects. Thrombocytosis-associated symptoms were relieved once the number of platelets was reduced to near normal levels. Marrow reticulin content was found to be reduced after treatment in two of the seven patients studied. Side effects of alpha interferon were flu-like symptoms, which usually subsided within 7 days of treatment.

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