氯苯(CB)与干扰素(α -2b)联合氯苯治疗低级别非霍奇金淋巴瘤的随机研究:一项随机研究的中期报告

Teodoro Chisesi , Marina Congiu , Antonio Contu , Paolo Coser , Luciano Moretti , Adolfo Porcellini , Laura Rancan VI , Luigi Salvagno , Gino Santini , Orazio Vinante , Non-Hodgkin's Lymphoma Cooperative Study Group
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引用次数: 31

摘要

α干扰素在治疗低级别非霍奇金淋巴瘤(NHL),尤其是结节性淋巴瘤方面显示出初步的前景。本研究招募了70名NHL患者,他们接受了氯苯(CB);10 mg/天)或CB加干扰素α -2b(500万单位(MU)/m2,每周皮下注射3次)。在63名可评估的患者中,治疗组的有效率相似(分别为62.1%和64.7%)。在未接受维持治疗的患者中,在诱导期接受干扰素α -2b治疗的患者与单独接受氯霉素治疗的患者相比,在复发发生率方面显示出有利的趋势。在干扰素α -2b维持治疗期间,与未接受维持治疗的患者相比,复发发生率未见显着差异。需要更长的观察期才能对干扰素维持治疗的有效性做出明确的结论,并进一步评估氯霉素和干扰素诱导联合方案对缓解持续时间的影响。
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Randomized study of chlorambucil (CB) compared to interferon (alfa-2b) combined with CB in low-grade non-Hodgkin's lymphoma: An interim report of a randomized study

Alpha interferon has shown initial promise in the treatment of low-grade non-Hodgkin's lymphoma (NHL), especially with the nodular form of the disease. The present study enrolled 70 NHL patients who received either chlorambucil (CB; 10 mg/day) or CB plus interferon alfa-2b (5 million units (MU)/m2 subcutaneously three times a week). Among 63 evaluable patients, similar response rates (62.1% and 64.7% respectively) were recorded for the treatment arms. In patients receiving no maintenance therapy, those who received interferon alfa-2b during the induction phase showed a favourable trend in terms of incidence of relapse compared to those who had received chlorambucil alone. During maintenance therapy with interferon alfa-2b, no significant differences in the occurrence of relapse have yet been seen compared to patients on no maintenance therapy. A longer observation period is needed to make a definitive conclusion about the usefulness of interferon maintenance therapy and to evaluate further the effects of the combined schedule of chlorambucil and interferon induction on the duration of remission.

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