利用微阵列和深度学习预测乳腺癌风险

R. M. Shanmu, P. Brundha, G. A. Swaminathan, R. T. Merlin, V. Hemamalini, M. Ramnath
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引用次数: 0

摘要

每年发现的乳腺癌新病例超过115万例。在临床上,只有少数可靠的预后和预测指标被用来决定乳腺癌患者的治疗。早期发现可以降低乳腺癌患者的死亡率,延长患者的生存时间。微阵列图像的分析和处理是用于筛查和早期诊断的主要测试,是改善乳腺癌预后的关键,也是本研究的核心。将模糊c均值(FCM)方法用于乳腺癌检测的微阵列图像分割。在从分割区域检索特征并对系统进行充分训练后,使用高效分类器将微阵列分配到各自的类中。采用多级离散小波变换、主成分分析(PCA)和灰度共生矩阵(GLCM)等技术提取纹理信息。借助形态学算子实现肿块和微阵列图像钙化与周围组织的区分,这些特征的分类由深度卷积神经网络(DCNN)算法处理。在微阵列中,肿瘤的边界被突出显示给医生,医生可以评估肿瘤的生长程度。
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Prediction of Breast Cancer Risk Using Microarrays and Deep Learning
More than 1.15 million new instances of breast cancer are identified each year. In the clinic, only a few reliable prognostic and predictive indicators are utilized to make decisions about the treatment of breast cancer patients. The mortality rate of breast cancer patients may be lowered and their survival time extended by early identification. Analysis and processing of Microarray images, the principal test used for screening and early diagnosis, are the keys to improving breast cancer prognosis and are at the heart of this study. The Fuzzy C-means (FCM) approach is used for image segmentation in microarray for the detection of breast cancer. After features are retrieved from the segmented areas and the system is fully trained, the efficient classifier is used to assign microarrays to their respective classes. Techniques such as Multi-level Discrete Wavelet Transform, Principal Component Analysis (PCA), and Gray-level Co-occurrence Matrix (GLCM) are used to extract texture information. Differentiating masses and microarray image calcifications from the surrounding tissue is achieved with the aid of morphological operators and the classification of these features is handled by the Deep Convolution Neural Network (DCNN) algorithm. In a microarray, the tumor’s borders are highlighted and exhibited to the doctor, who may then assess the extent of the growth.
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