类风湿关节炎患者血清中白细胞介素-2可溶性受体的水平。

Czechoslovak medicine Pub Date : 1991-01-01

K Pavelka

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引用次数: 0

摘要

作者采用夹心酶免疫分析法(ELISA)对白细胞介素-2可溶性受体(s-r IL-2)进行了评估。类风湿关节炎患者的平均值为620.5 = 500.0 u /ml，显著高于骨关节炎患者(313.3 +/- 155 n /ml)和健康对照组(181.7 +/- 159.6 n /ml) (p < 0.001)。在类风湿关节炎患者中，用Lansbury指数表示的疾病活动性之间存在相关性(r = 0.61, p < 0.01)。s-r IL-2与沉降速率无相关性(r = 0.32, p = n.s)。作者回顾了文献并讨论了s-r IL-2作为白介素-2的竞争性抑制剂的假设。

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Levels of the soluble receptor for interleukin-2 in serum of patients with rheumatoid arthritis.

The authors assessed, using the method of sandwich enzyme immunoassay (ELISA), the soluble receptor for interleukin-2 (s-r IL-2). In patients with rheumatoid arthritis mean values of 620.5 = 500.0 u./ml were recorded which was significantly higher than in patients with osteoarthritis (p less than 0.001) (313.3 +/- 155 n./ml) and in healthy controls (181.7 +/- 159.6 n./ml). In patients with rheumatoid arthritis a correlation was found between the activity of the disease expressed by means of Lansbury's index (r = 0.61, p less than 0.01). There was no correlation between s-r IL-2 and the sedimentation rate (r = 0.32, p = n.s.). The author reviews the literature and discusses the hypothesis that s-r IL-2 acts as a competitive inhibitor for interleukin-2.

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Czechoslovak medicine

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