Clinical evaluation of the efficacy of antituberculosis chemotherapy. A review of its methods.

The various methods for the evaluation of the efficacy of chemotherapy in pulmonary and extrapulmonary tuberculosis that have been developed over time are described, and their rationale is discussed. With growing experience and improvement of efficacy an ongoing need for change of techniques is to be observed, in the end always leading to higher specificity, sensitivity and reproducibility of evaluation.