Gastric-Type Adenocarcinoma in-Situ of the Uterine Cervix: An Emerging Entity

Gastric-Type Adenocarcinoma (GAS) is a rare and aggressive subtype of endocervical adenocarcinoma. Accumulated evidence suggests that a subset of atypical Lobular Endocervical Glandular Hyperplasia (LEGH) and Gastric Type Adenocarcinoma in Situ (GAIS) may be associated with and represent precursors of GAS. GAIS is rare and not yet well characterised. Herein, we summarise the current available literature on histological and cytological features of GAIS. GAS and GAIS are likely to increase in relative importance in the era of HPV vaccination and HPV testing, yet will prove a diagnostic challenge due to lack of familiarity, subtle histologic and cytologic features and lack of association with HPV.