P Rekowski, U Galasik-Bartoszek, A Plech, R Brus, G Kupryszewski
{"title":"抗压素及其类似物:合成、抗利尿和行为作用。","authors":"P Rekowski, U Galasik-Bartoszek, A Plech, R Brus, G Kupryszewski","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>[Lys8]-Conopressin G (L1), and [Arg8]-Conopressin S (A1) and their four analogs were synthesized using solid phase procedure. These analogs are [2-thiopropionic acid1, lys8]-conopressin (L2), [2-thiopropionic acid1, Arg8]-conopressin (A2), [cis-4-methyl-1-thiocyclohexaneacetic acid1, Lys8], conopressin (L3), and [cis-4-methyl-1-thiocyclohexaneacetic acid1, ARg8]-conopressin (A3). Behavioral and diuretic effects of all six peptides were compared with these of [Arg8]-vasopressin (AVP). Conopressin A1, and L1 and their analogs A2, A3, L2, L3, induced antidiuretic effects. After icv injection of some conopressins, barrel rotatory behavior of rats was observed.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 5","pages":"361-7"},"PeriodicalIF":0.0000,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conopressins and their analogs: synthesis, antidiuretic and behavioral effects.\",\"authors\":\"P Rekowski, U Galasik-Bartoszek, A Plech, R Brus, G Kupryszewski\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>[Lys8]-Conopressin G (L1), and [Arg8]-Conopressin S (A1) and their four analogs were synthesized using solid phase procedure. These analogs are [2-thiopropionic acid1, lys8]-conopressin (L2), [2-thiopropionic acid1, Arg8]-conopressin (A2), [cis-4-methyl-1-thiocyclohexaneacetic acid1, Lys8], conopressin (L3), and [cis-4-methyl-1-thiocyclohexaneacetic acid1, ARg8]-conopressin (A3). Behavioral and diuretic effects of all six peptides were compared with these of [Arg8]-vasopressin (AVP). Conopressin A1, and L1 and their analogs A2, A3, L2, L3, induced antidiuretic effects. After icv injection of some conopressins, barrel rotatory behavior of rats was observed.</p>\",\"PeriodicalId\":20276,\"journal\":{\"name\":\"Polish journal of pharmacology and pharmacy\",\"volume\":\"43 5\",\"pages\":\"361-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polish journal of pharmacology and pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polish journal of pharmacology and pharmacy","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
采用固相法合成了[Lys8]-Conopressin G (L1)和[Arg8]-Conopressin S (A1)及其四种类似物。这些类似物是[2-硫代丙酸1,lys8]-抗压素(L2)，[2-硫代丙酸1,Arg8]-抗压素(A2)，[顺-4-甲基-1-硫代环己烷乙酸1,lys8]，抗压素(L3)和[顺-4-甲基-1-硫代环己烷乙酸1,Arg8]-抗压素(A3)。将所有6种多肽与[Arg8]-抗利尿素(AVP)的行为和利尿作用进行比较。抗利尿素A1，和L1及其类似物A2, A3, L2, L3诱导抗利尿作用。注射抗压素后，观察大鼠的转桶行为。
Conopressins and their analogs: synthesis, antidiuretic and behavioral effects.
[Lys8]-Conopressin G (L1), and [Arg8]-Conopressin S (A1) and their four analogs were synthesized using solid phase procedure. These analogs are [2-thiopropionic acid1, lys8]-conopressin (L2), [2-thiopropionic acid1, Arg8]-conopressin (A2), [cis-4-methyl-1-thiocyclohexaneacetic acid1, Lys8], conopressin (L3), and [cis-4-methyl-1-thiocyclohexaneacetic acid1, ARg8]-conopressin (A3). Behavioral and diuretic effects of all six peptides were compared with these of [Arg8]-vasopressin (AVP). Conopressin A1, and L1 and their analogs A2, A3, L2, L3, induced antidiuretic effects. After icv injection of some conopressins, barrel rotatory behavior of rats was observed.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
