锌缺乏对小鼠吞噬功能的影响。

K Tone, T Suzuki, T Todoroki
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引用次数: 0

摘要

以活性氧生成为参数,研究了吞噬活性对锌缺乏小鼠早期防御机制的影响,得到的结果如下:与正常小鼠相比,锌缺乏小鼠的体重明显下降。2. 锌缺乏组肝脏和血液锌含量低于锌充足组和对照组(P < 0.01)。3.在早期防御机制中起主导作用的腹腔内(i.p.)细胞的数量在锌缺乏小鼠中显示出低于正常小鼠的水平。4. 通过活性氧的产生来测量吞噬活性,发现锌缺乏小鼠的活性氧活性受损。5. 通过对ipp细胞和血细胞的分型,证实了淋巴细胞(lym.)是锌缺乏小鼠ipp细胞和血细胞的主要细胞(68.5%和73.8%)。对照组(未治疗的小鼠)和锌充足组表现出与这些锌缺乏小鼠相似的模式。
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Influence of zinc deficiency on phagocytosis in mice.

The influence of phagocytic activity on the early stage defence mechanisms in zinc deficient mice was studied using active oxygen production as a parameter and the results obtained were as follows: 1. The body weight of the zinc deficient mice was decreased significantly compared with that of the normal mice. 2. Zinc levels in the liver and blood of the zinc deficient group showed low comparing with the zinc adequate and the control groups (P less than 0.01). 3. The numbers of intraperitoneal (i.p.) cells, which play a leading role in early stage defense mechanisms, showed lower levels in the zinc deficient mice than that of the normal mice. 4. Phagocytic activity was measured as active oxygen production and this activity was found to be impaired in zinc deficient mice. 5. After the typing of i.p. cells and blood cells, it was proved that lymphocyte (lym.) was the main cell (68.5% and 73.8%) in i.p. cells and blood cells of the zinc deficient mice. The control group (non-treated mice) and the zinc adequate group showed a similar pattern of these zinc deficient mice.

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