胸腺胺对角膜内皮的影响。

Lens and eye toxicity research Pub Date : 1991-01-01

K Green, J M Chapman, L Cheeks, D S Hull

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摘要

研究了0.02和0.2%盐酸百里香胺对离体兔角膜内皮的影响。通过镜面显微镜测量的角膜肿胀率表明，0.02%的百里香胺引起的肿胀率与对照组相同，而0.2%的浓度引起的肿胀率显著增加(34.1 vs 10.3微米/小时;P < 0.05)。数据表明，为了使角膜内皮的安全系数达到10倍，推荐的最大胸腺胺内窥镜浓度为0.02%。

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Effects of thymoxamine on corneal endothelium.

We have investigated the effects of 0.02 and 0.2% thymoxamine hydrochloride on the isolated rabbit corneal endothelium. The corneal swelling rate, measured by specular microscopy, indicated that 0.02% thymoxamine caused a swelling rate equal to controls while a 0.2% concentration caused a significantly increased swelling rate (34.1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium.

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Lens and eye toxicity research

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