不典型增生和宫颈癌的自然史:多伦多队列研究的早期结果

Steven A. Narod , D.W. Thompson , M. Jain , Claus Wall , Lois M. Green , Anthony B. Miller
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引用次数: 19

摘要

从一个大型细胞病理学实验室1962年至1981年的记录中提取了来自70236名妇女的1776808份巴氏涂片样本。根据最初涂片结果的分布,在研究期间,宫颈发育不良的患病率从每1000人42.7人上升到94.9人。与整个队列相比,轻度、轻度、中度和重度发育不良妇女在随后的子宫颈涂片中表现为恶性肿瘤(原位癌或更严重)的相对风险(RR)分别为1.48、3.42、20.9和71.5。发展为恶性肿瘤的女性的初始发育不良程度更有可能被解释为中度(RR = 5.0)或重度(RR = 42.3)。这些结果有力地支持了发育不良程度与宫颈癌发生风险相关的假设。
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Dysplasia and the natural history of cervical cancer: Early results of the Toronto cohort study

A sample of 176 808 Pap smears, taken from 70 236 women, was constructed from the records of a large cytopathology laboratory between 1962 and 1981. The prevalence of cervical dysplasia, based on the distribution of initial smear results, rose from 42.7 to 94.9 per 1000 during the study period. The relative risks (RR) for the manifestation of a malignancy (carcinoma in situ or worse) in a subsequent cervical smear were 1.48, 3.42, 20.9 and 71.5 for women with minimal, mild, moderate and severe dysplasia, respectively, compared with the entire cohort. The initial degree of dysplasia for women developing a malignancy was much more likely to be interpreted as moderate (RR = 5.0) or severe (RR = 42.3) than were those for controls. These results are strongly supportive of the hypothesis that the degree of dysplasia is related to the risk of development of cancer of the cervix.

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