结直肠癌生存率的集成学习

C. Roadknight, U. Aickelin, J. Scholefield, L. Durrant
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引用次数: 3

摘要

在本文中,我们描述了一个与手术切除结肠直肠肿瘤的患者的细胞和身体状况相关的数据集。该数据为肿瘤切除、肿瘤分类和术后生存的免疫状态提供了独特的见解。我们建立在现有的数据聚类和机器学习方面的研究基础上,以证明集成方法在突出具有更清晰预后参数的患者方面的作用。对于最难建模的数据子集,显示了使用3种不同方法的生存预测结果。将每个模型的性能单独与多个模型达到某种一致的数据子集进行比较。对于模型之间达成一致的患者,可以在未见的测试集上实现模型精度的显着改进。
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Ensemble learning of colorectal cancer survival rates
In this paper, we describe a dataset relating to cellular and physical conditions of patients who are operated upon to remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal, tumour classification and post-operative survival. We build on existing research on clustering and machine learning facets of this data to demonstrate a role for an ensemble approach to highlighting patients with clearer prognosis parameters. Results for survival prediction using 3 different approaches are shown for a subset of the data which is most difficult to model. The performance of each model individually is compared with subsets of the data where some agreement is reached for multiple models. Significant improvements in model accuracy on an unseen test set can be achieved for patients where agreement between models is achieved.
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