涉及环GMP的内皮依赖性和非依赖性血管舒张:一氧化氮、一氧化碳和光诱导的舒张。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158843
R F Furchgott, D Jothianandan
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引用次数: 516

摘要

比较了一氧化碳(CO)诱导的、内皮依赖性的兔主动脉舒张与一氧化氮(NO)诱导的、光诱导的、内皮依赖性舒张因子(EDRF)介导的血管舒张的特点。一氧化碳作为松弛剂的效力不及一氧化氮的千分之一。各种发现,包括与CO诱导的松弛相关的环GMP的增加,得出CO-像NO, EDRF和光一样-通过刺激鸟苷酸环化酶而产生松弛的结论。产生超氧化物的LY 83583是乙酰胆碱诱导的内皮依赖性松弛和一氧化氮诱导的松弛的有效速效抑制剂,也是一种相当有效的中速效光松弛抑制剂,但对co诱导的松弛仅是一种非常弱的抑制剂。LY 83583和血红蛋白抑制光松弛的能力与辐射下形成光诱导松弛因子的假设一致,该因子可以刺激鸟苷酸环化酶,并且可以被超氧化物和血红蛋白灭活。
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Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light.

The characteristics of carbon monoxide (CO)-induced, endothelium-independent relaxation of rabbit aorta were compared with those of nitric oxide (NO)-induced and light-induced relaxation and endothelium-dependent relaxation mediated by endothelium-dependent relaxing factor (EDRF). CO was less than one thousandth as potent as NO as a relaxant. Various findings, including an increase in cyclic GMP associated with CO-induced relaxation, led to the conclusion that CO - like NO, EDRF and light - produces relaxation as a result of its stimulation of guanylate cyclase. LY 83583, which generates superoxide, was a potent, fast-acting inhibitor of acetylcholine-induced endothelium-dependent relaxation and NO-induced relaxation, and a fairly potent, moderately fast-acting inhibitor of photorelaxation, but only a very weak inhibitor of CO-induced relaxation. The ability of LY 83583 as well as hemoglobin to inhibit photorelaxation is consistent with the hypothesis that on radiation a photo-induced relaxing factor is formed which can stimulate guanylate cyclase and which can be inactivated by superoxide and by hemoglobin.

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