一种脉冲神经模型中不同注入电流下膜电阻对脉冲宽度和振幅的影响

S. Pilehvari, Lei Zhang, R. Mayorga
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引用次数: 1

摘要

神经元作为大脑的基本处理单元和神经系统起着至关重要的作用。如果一个神经元得到适当的刺激,它就会产生沿轴突传递的动作电位。到达神经元末端时,其他神经元或肌肉细胞可能被激活[1]。神经形态、树突厚度和被动电参数对脑电波宽度和振幅的影响可以通过脑电波模型的解析和数值研究来研究。上述适当刺激的作用可能随着时间的推移而减弱。本文尝试在著名的四维霍奇金-赫胥黎模型中加入有效参数“膜电阻”来比较由于电阻变化和注入电流不同而产生的几种输出。本文的目标是测量尖峰变化,甚至如何确定电流阈值,当电阻不恒定(非线性时间依赖)的不同因素的结果。
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Impact of Membrane Resistance on Width and Amplitude of Spikes in Different Injected Currents in One Spiking Neural Model
Neurons in the brain as the elementary processing units and nervous system play a key role. If a neuron gets a proper stimulus, it produces action potentials (spikes) that are transferred along its axon. Reaching the end of the neuron, other neurons or muscle cells may be activated [1]. The effect of neural morphology along with thickness of dendrites and passive electrical parameters on the spikes width and amplitude can be investigated by analytical and numerical investigations of spiking models. The impact of mentioned proper stimulus may be degraded by passing time. In this paper, it is tried to add the effective parameter ’membrane resistance’ in well-known Hodgkin-Huxley model with four dimensions to compare several outputs due to changing resistance and various injected current. The goal of this paper has been to measure spikes changes or even how to determine current threshold when resistance is not constant (non-linear time dependant) result of different factors.
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