微RNA:癌症的重要生物标志物

Dr. Hiba Sabah Jasim
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摘要

MicroRNAs是一组短的非编码rna,通过与相应mrna的匹配,在转录后控制基因的表达。微rna的下调可能被认为是一种新型的“肿瘤抑制剂”或“肿瘤抑制因子”,在肿瘤的发生发展中起着重要作用。利用全基因组检测技术,常见的不稳定表达类型的微rna已经在人类癌症的广泛分布中得到了识别,显示出巨大的潜力,作为现代检测和预测因素,提高了正常程度,提高了敏感性和特异性。血液和体液中可诊断的微RNA随稳定性的提高,为癌症病例中基于微RNA的药物提供了丰富的来源。尽管越来越多的微RNA药物已经确定,但基于微RNA的药物从药物到床边的传播仍然是重要的治疗和控制面临许多挑战。本研究将全面展示微rna在人类癌症中的重要作用。
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Micro RNA the Important Biomarker in Cancer
MicroRNAs are a set of short noncoding RNAs that post transcriptionally control the gene expression through matching with its corresponding mRNAs. The down regulated of micro RNAs may be suggested as a novel kind of “oncomirs”or “tumor suppressors,” acting an important effect in the development of carcinoma. Employing genome wide detection techniques, common erratic expression types of micro RNAs have been recognized in a wide arrangement of cancers in human, demonstrate huge potential as modern detection and predictive agents of up normality and elevation of sensitivity and specificity. The diagnosable micro RNAs in blood and the further body fluids with rise constancy supply a profuse origin for micro RNA based agents in cancer cases. In spite of the verity that a growing number of effort micro RNA agents have been determinate, the transmission of micro RNAs based agents from board to bedside as yet important treatment and control many challenges. This study will demonstrate the recent comprehensive of micro RNAs as important agents in cancer of human.
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