Fabrication of Hybrid Composites Consists of Poly Methyl Methacrylate and Polyvinyl Alcohol and Hydroxyapatite

The weakness of bone plate made up from metal alloys and almost ceramics as well as thermosetting polymers is non biodegradable or very slow biodegradable. Thermoplastic and elastomeric polymers are degradable with various rates. A composite consisted of these polymers could be adjusted for required biodegradable rate. Beside, the composites would overcome mechanical behavior requirements to become promising device in tissue engineering. To support this point, fine hydroxyapatite (HAp) particles were penetrated in the composite. A hybrid composite with polymer mixture with HAp was fabricated by electrospinning method. Poly methyl methacrylate (PMMA) is a thermoplastic polymer, it was demon- strated good biocompatibility. However, PMMA inhibited inappropriate degradable rate in prosthetic treatment. Polyvinyl alcohol (PVA) is an elastomeric polymer; it has good biocompatibility, and rapidly bioabsorbable. These polymers were sprayed by electrospinning machine to form mats. HAp, was synthesized by microwave assisted process, and the contents in the composites were 0%, 2%, 4% and 6% by weight. Warm-pressing process was applied to form bone plate from mats. In MTT assay, the composites were non-toxic and showed good biocompatibility.