单剂量哌拉西林/他唑巴坦在经直肠前列腺活检中的预防作用

J.O. Herrera-Caceres , C.I. Villeda-Sandoval , J. Ruiz-Quiñones , P. De-La-Rosa-Leiva , R.A. Castillejos-Molina , G. Feria-Bernal , A. Galindo-Fraga , F. Rodriguez-Covarrubias
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引用次数: 1

摘要

背景:对喹诺酮类药物耐药性的增加导致考虑其他抗生素的选择,以预防前列腺活检中的感染性并发症。我们介绍我们使用单剂量哌拉西林/他唑巴坦作为预防的经验。方法回顾性分析2008 ~ 2013年在我院行经直肠前列腺活检的病例。所有患者在活检前均接受灌肠,并在活检前几分钟静脉注射单剂量4.5 g哌拉西林/他唑巴坦。分析临床和微生物变量,找出并发症的危险因素。结果共纳入543例活组织检查。74例(13.6%)患者报告92例(16.9%)并发症,其中4.2%为感染性并发症。在这些患者中,相关的危险因素是活检前3年内尿培养阳性病史,活检时存在经尿道留置导管,活检前1个月内住院,术前尿培养阳性,尽管根据耐药性模式选择了抗生素治疗。结论医生和患者应意识到并发症的风险,特别是如果存在危险因素。单剂量哌拉西林/他唑巴坦是一种合理的预防选择,特别是在喹诺酮耐药病原体高发的国家。
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Single-dose piperacillin/tazobactam as prophylaxis in transrectal prostate biopsy

Background

The increasing resistance to quinolones has led to the consideration of other antibiotic options for the prevention of infectious complications in prostate biopsy. We present our experience using a single dose of piperacillin/tazobactam as prophylaxis.

Methods

A retrospective study of transrectal prostate biopsies performed at our institution from 2008 to 2013 was conducted. All patients received enemas before biopsy and a single 4.5 g dose of piperacillin/tazobactam was administered i.v. a few minutes before the biopsy. Clinical and microbiological variables were analyzed to find out risk factors for complications.

Results

A total of 543 biopsies were included. Ninety-two complications (16.9%) were reported in 74 (13.6%) patients, 4.2% of which were infectious complications. In these patients, the associated risk factors were a previous history of positive urine cultures within a 3-year period before biopsy, the presence of a transurethral indwelling catheter at the time of the biopsy, hospital admission within a month before biopsy, and a preoperative positive urine culture despite antibiotic therapy selected according to the resistance pattern.

Conclusions

Physicians and patients should be aware of the risk for complications, particularly if risk factors are present. A single dose of piperacillin/tazobactam is a reasonable option for prophylaxis, especially in countries with a high prevalence of quinolone-resistant pathogens.

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来源期刊
Revista mexicana de urologia
Revista mexicana de urologia Medicine-Urology
CiteScore
0.20
自引率
0.00%
发文量
49
期刊介绍: Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.
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