Anisimova OYu, E A Volynskaya, T I Kuzmina, A B Danilevich
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Dynamic model of 99mTc-labelled lipoprotein accumulation in rabbit liver.
To create a mathematical model to describe the receptor-mediated accumulation of 99mTc-labelled lipoproteins in rabbit liver, a set of differential equations was devised for the simplest case: that involving one ligand and one receptor. Normal and hypercholesterolemic rabbits were included in gammascintigraphic trials as having normal and reduced numbers, respectively, of liver low-density lipoprotein (LDL) receptors. The system described may have clinical applications as a quick and effective method of assessment of LDL uptake by the liver.
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