[A new method for the determination of circulating blood volume--erythrocyte marking with sodium fluorescein].

The knowledge of circulating blood volume extends the possibility of judgement of the circulation status and is a valuable help for the management of volume therapy. Blood volume measurements are rarely done in clinical practice in underestimation of their value for the therapy because of their high technical expense, long duration of examination, bad repeatability and radiation exposure. A method for blood volume determination which possesses more favorable abilities than known radioactive methods has been developed by staining red cells with fluorescein sodium. This paper presents an insight into the method and examines the reliability of measurement by means of repeated determinations in vivo.