狂犬病毒单克隆抗体的结合特性。

Microbiologica Pub Date : 1991-07-01
M G Cusi, P E Valensin, M Tollis, L Bracci, S Petreni, P Soldani
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引用次数: 0

摘要

用与乙酰胆碱受体(AchR)结合的狂犬病毒糖蛋白190 ~ 203区对应的四肽段免疫小鼠获得的单克隆抗体(mab)对不同的狂犬病毒株表现出不同的特异性。当这些单克隆抗体用于免疫荧光试验时,可以区分野生狂犬病毒和减毒狂犬病毒。
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Binding properties of monoclonal antibodies to rabies virus.

The monoclonal antibodies (mAbs) obtained by immunizing mice with a tetradecapeptide corresponding to the 190-203 region of rabies virus glycoprotein, involved in binding to the acetylcholine receptor (AchR), displayed different specificities to different rabies virus strains. These mAbs, when used in immunofluorescence tests, allowed differentiation of wild rabies viruses from the attenuated ones.

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