基于深度学习的基因表达分类

O. Ahmed, A. Brifcani
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引用次数: 45

摘要

基因表达的分类是生物信息学中一个重要的研究课题。基因表达数据通常具有特征多样本少的特点。基因表达数据之间的差异很大,数据之间的差异性和特征数量的庞大给基因表达数据的分类带来了挑战。在本研究中,我们评估了最强大的深度学习算法(如深度神经网络、循环神经网络、卷积神经网络和带有预处理技术的改进深度神经网络)的分类准确性。通过加入Dropout对DNN进行改进,克服了过拟合问题。结果表明,改进的深度神经网络在所有使用的数据集上都优于其他算法。
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Gene Expression Classification Based on Deep Learning
One of the most significant research topics in bioinformatics is the classification of gene expression. Gene expression data commonly have a large number of features and a small number of samples. The gene expression data are very different from one to another, this differentiation among data and the feature’s large number make the classification for gene expression data challenging. In this study, for classification we assessed the accuracy for most powerful deep learning’s algorithms such as Deep Neural Network, Recurrent Neural Network, Convolutional Neural Network and improved Deep Neural Network with the preprocessing technique. The DNN was improved by adding Dropout to it by which the overfitting problem was overcame. Our results showed that the proposed improved-DNN outperforms the other algorithms among all used datasets.
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