血管搭桥手术治疗儿童肝外门静脉高压症(综述)

Z. Mitupov, A. Razumovsky, V. Rachkov, N. Kulikova, S. Margaryan
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摘要

在患有肝外门脉高压(HSV)的儿童中,最常见和危及生命的并发症是食道和胃静脉曲张出血。因此,单纯疱疹病毒治疗的主要任务是防止上消化道静脉出血。最有效的治疗方法是门静脉搭桥手术(PSS),其有效性可达94-97%。然而,正是由于门静脉肝灌注(PPP)减少和门静脉系统性脑病(PSE)的发展,这些手术的使用受到限制。目的是分析国内外关于门静脉高压症手术治疗及门静脉全身性脑病术后发展的文献。系统检索PubMed、Web of Science、Scopus、MEDLINE、library、RSCI、Cyberleninka等数据库,分析文献345篇,复习文献110篇,选择门静脉高压症手术治疗相关文献97篇。术后PSE的发展通常发生在全PSS植入之后。为了降低发生PSE的风险,选择性分流术在一定程度上保护了PPP。远端脾肾吻合(DSRA)的PE发生率小于10-15%。中间位置为侧对侧脾肾吻合,有选择性手术的迹象。文献来源分析的结果显示,关于HSV患者的最佳治疗策略的选择,内镜方法预防胃肠道出血的位置和作用,以及门静脉分流术(MPSH)在肝外PG患者治疗中的作用仍在讨论中。世界上大多数专家认为MPSH是预防静脉曲张出血和其他HSV并发症的一级和二级预防的最佳手术。如果无法完成,可选择DSRA旁路手术作为MPSH的替代方案。
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Vascular bypass surgery in the treatment of extrahepatic portal hypertension in children (review)
In children with extrahepatic portal hypertension (HSV), the most frequent and life-threatening complication is bleeding from varicose veins of the esophagus and stomach. Therefore, the main task of HSV treatment is to prevent bleeding from the veins of the upper gastrointestinal tract. The most effective treatment is portosystem bypass surgery (PSS), the effectiveness of which reaches 94-97%. However, the use of these operations is limited precisely because of a decrease in portal liver perfusion (PPP) and the development of portosystemic encephalopathy (PSE). The aim is to analyze domestic and foreign publications devoted to the surgical treatment of portal hypertension and the development of portosystemic encephalopathy in the postoperative period. A systematic search was carried out in the databases PubMed, Web of Science, Scopus, MEDLINE, eLibrary, RSCI, Cyberleninka. 345 references were analyzed, 110 articles were reviewed, 97 publications on surgical treatment of portal hypertension were selected for the review. The development of PSE in the postoperative period often occurs after the imposition of total PSS. To reduce the risk of developing PSE, selective shunts have been developed, which to some extent preserve the PPP. With distal splenorenal anastomosis (DSRA), the frequency of PE is less than 10-15%. An intermediate position is occupied by a side-to-side splenorenal anastomosis, which has signs of selective surgery. The results of the analysis of literature sources showed that discussions are still underway regarding the choice of the optimal treatment strategy for patients with HSV, the place and role of endoscopic methods for the prevention of gastrointestinal bleeding, as well as mesoportal shunt (MPSH) in the treatment of patients with extrahepatic PG. Nevertheless, the majority of world experts consider MPSH to be the most optimal operation for primary and secondary prevention of varicose bleeding and other complications of HSV. And if it is impossible to perform it, the operation of selective bypass surgery of the DSRA can serve as an alternative to performing MPSH.
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