纳米银胶体牙齿凝胶治疗口腔疾病的疗效:一项前瞻性、随机、三组、平行、双盲对照介入临床研究

Shashank Tiwari, S. Mahale, Amit Keshav Walvekar, Rajlaxmi D Patil, S. Harish, Anirudh Mehta, S. S. Jadhav
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引用次数: 0

摘要

目的:口腔健康状况不佳是导致各种口腔疾病的根本原因,如龋齿、牙周病、错颌、口面异常等,这些疾病会导致疼痛、痛苦甚至残疾。全球约有35亿人患有一种或另一种牙齿疾病。此外,牙齿健康状况不佳也会导致许多全身性疾病。需要新的治疗药物来防止龋齿和牙菌斑的形成,从而保护牙齿免受进一步的损害。胶体纳米银(SilverSol®)牙齿凝胶是一种胶体纳米银制剂,与木糖醇和薄荷油一起使用,具有独特的生物破坏性纳米技术,由于其伤口愈合和抗菌特性,具有多维活性。方法:本研究对120例患有不同牙病的患者进行了研究,以评估SilverSol®牙齿凝胶的疗效。结果:SilverSol®在几乎所有监测的患者中都显示出显著的效果。口腔外牙斑和牙袋深度评分分别下降58.6%和52.2%。呼吸异味也有所改善,得分降低了66%。总的来说,它对整体口腔健康的改善贡献了69%。结论:与氯己定凝胶相比,SilverSol®牙齿凝胶对包括牙周炎和牙龈炎在内的几种口腔疾病有效。定期使用SilverSol®牙齿凝胶可以预防这些情况,并保持牙齿的整体健康。
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Efficacy of Colloidal Nanosilver Tooth Gel in the Management of Orodental Conditions: A Prospective, Randomized, Triple Arm, Parallel, Double-blind Controlled Interventional Clinical Study
Objective: Poor orodental health is a root cause of various oral conditions, viz., dental caries, periodontal diseases, malocclusion, orofacial anomalies, and many more that result in pain, suffering, and even disability. Around 3.5 billion population suffers from one or the other dental condition globally. Moreover, poor orodental health also contributes to many systemic diseases. The newer therapeutic agents are needed to prevent dental caries and plaque formation and thereby protect teeth from further damage. Colloidal Nanosilver (SilverSol®) Tooth Gel is a colloidal nanosilver preparation along with xylitol and peppermint oil with a unique biodisruptive nanotechnology having multidimensional activity due to its wound healing and antimicrobial properties. Methodology: The present study was conducted on 120 patients suffering from different dental conditions to assess the efficacy of SilverSol® Tooth Gel. Results: SilverSol® showed a significant effect in almost all the conditions monitored in the patients. There was a reduction in extrinsic tooth stains and pocket depth score in the mouth by 58.6 and 52.2% respectively. Breath malodor also showed improvement as the score reduced by 66%. Altogether, it contributed to the overall oral health improvement by 69%. Conclusion: SilverSol® Tooth Gel is effective in several orodental conditions including periodontitis and gingivitis in comparison to chlorhexidine gel. Routine application of SilverSol® Tooth Gel will prevent these conditions and maintain the overall orodental health.
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