长期给药尼古丁不能改变mptp诱导的小鼠神经毒性。

General pharmacology Pub Date : 1991-01-01 DOI:10.1016/0306-3623(91)90075-h

Y K Fung, L A Fiske, Y S Lau

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引用次数: 22

摘要

1. 研究了慢性(14天)给药1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP) (15 mg/kg, s.c)对C57BL/6小鼠神经毒性的影响。2. 尼古丁预处理不能改变运动活动的缺陷和MPTP产生的纹状体多巴胺水平的降低。3.我们的研究结果不支持尼古丁在帕金森病动物模型中的治疗作用。

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Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice.

1. The effects of chronic (14 day) administration of nicotine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (15 mg/kg, s.c.)-induced neurotoxicity in C57BL/6 mice were examined. 2. Nicotine pretreatment failed to alter the deficit in locomotor activity and the reduction in striatal levels of dopamine produced by MPTP. 3. Our results do not support a therapeutic action of nicotine in a Parkinsonian animal model.

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General pharmacology

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