用介电光谱法预测酵母细胞悬浮液的物理性质

D. J. Currie, M.H. Lee, R. Todd
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引用次数: 1

摘要

这项工作涉及生物细胞悬浮液介电特性的建模。悬浮液的相对介电常数与悬浮细胞的体积分数成正比,但分别知道平均细胞半径和细胞数密度会更有用。基于Levenberg-Marquardt技术的非线性最小二乘算法已经开发出来,可以使用简单的球壳模型和Cole-Cole方程来预测这些工业上重要的细胞特征。一个新的RC电路模型的典型细胞也已开发,试图解释电学性质的细胞悬浮液。
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Prediction of physical properties of yeast cell suspensions using dielectric spectroscopy
This work concerns the modelling of the dielectric properties of biological cell suspensions. The relative permittivity of a suspension is proportional to the volume fraction of suspended cells but it would be more useful to know the average cell radius and number density separately. A non-linear least squares algorithm, based on the Levenberg-Marquardt technique, has been developed to predict these industrially important cell features using a simple spherical shell model along with the Cole-Cole equation. A new RC circuit model of a typical cell has also been developed to try to explain the electrical properties of a cell suspension.
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